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ղ̲ Dz N. O.Zarivna Studing of flavonoids - aglycone in wild thyme I. Horbachevsky Ternopil State Medical University Introduction. Wild thyme (Thymus ...

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N. O.Zarivna

Studing of flavonoids - aglycone in wild thyme

I. Horbachevsky Ternopil State Medical University

Introduction. Wild thyme (Thymus serpyllum), Lamiaceae family, is naturally spread in

wild in Ukraine and extensively cultivated. According to the reports wild thyme contains

flavonoids, tannins, phenol carbonic acid, essential oil, etc., which in combination condition the diverse pharmacological activity of the raw material and substances derived.

Materials and methods. Identification of aglikon flavonoids was performed by thin layer chromatography after hydrolysis of all flavonoids-glycosides to aglycones;

extraction of the aglycones was carried out with ethyl acetate formed with subsequent evaporation and dissolving the resulting residue in methanol. Quantitation was carried out by differential spectrophotometry, in terms of the equivalent amount of hyperoside.

Results and conclusions. As a result of TLC analysis, we have identified: luteolin, kaempferol, quercetin, apigenin, mirytsytyn, izoramnetyn. It was established that quantitative flavonoid content in industrial and wild samples of thyme raw was different: 0.68-0.75% - in industrial series and 0.49-0.54% - in wild samples collected in Western Ukraine, in terms of the equivalent amount of hyperoside.

Key words: herb, wild thyme, flavonoids, chromatography, spectrophotometry.

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V.S.Kyslychenko, V. Yu.Kuznetsova, Yu. S.Kolisnyk Justification of the necessity of the monograph on shepherd's purse herb to be included in the state pharmacopoeia of Ukraine National University of Pharmacy, Kharkiv, Ukraine Introduction. One of the most important sources for the development of drugs is a medicinal plant material. Appropriate quality and proven pharmacological activity are necessary requirements to use medicinal plant raw material. Quality of medicinal plant raw materials and herbal medicines in Ukraine is regulated by monographs included into the State Pharmacopoeia of Ukraine. The monographs are represented by a national part and harmonized with the European Pharmacopoeia.

Material and methods. This article offers the results of a comparative analysis of the information on shepherd's purse herb, which is presented in the USSRs Pharmacopeia ( editions VIII-XI) and British Herbal Pharmacopoeia.

Results and conclusions. It was found that neither modern methods of identification of biologically active substances containing in shepherd's purse herb nor quantification techniques represented in both kinds of Pharmacopea. It suggests the urgency of developing the national monograph on a popular medicinal herb, shepherd's purse, to be included into the State Pharmacopoeia of Ukraine.

Key words: Shepherd's purse, State Pharmacopoeia of Ukraine

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